Thrombin and factor Xa link the coagulation system with liver fibrosis.

These results are corroborated by our gel contraction assay, in which we were able to quantify a highly significant increase in gel contraction when FXa and thrombin were administered in combination compared to alone.

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This represented only a 13 and 9% reduction respectively compared to control mice and did not reach statistical significance (Fig. 4 ).

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