A large electronic-health-record-based genome-wide study of serum lipids.

Of the 46 SNPs, 17 Bonferroni-replicated ( P <0.05/46=0.0011), and 14 additional were nominally significant ( P =0.05); there was a clear distributional enrichment for smaller P -values, e.g., 67% met nominal or better significance, far more than the 2.5% expected by chance (requiring same direction; Supplementary Figure 4 ).

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These differences may reflect in part the divergence in allele frequencies for SNPs at the same loci in different ancestral groups; we see an overall trend towards lower minor-allele frequencies (and thus lower variance) in East Asians and African Americans independent of direction of effect ( Supplementary Figure 12 ).

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