Genetic overlap between endometriosis and endometrial cancer: evidence from cross-disease genetic correlation and GWAS meta-analyses.

The SECA primary test for the overlap of associated effects, including all 144 SNP subsets, revealed more subsets than expected by chance showing at least nominally significant pleiotropy between endometriosis and endometrial cancer ( P = 6.0 × 10 −3 ): The pair of SNP subsets producing the minimum exact binomial test P ‐value for pleiotropy (endometriosis SNP subset with P ≤ 0.002 and endometrial cancer SNP subset with P ≤ 0.86) had P = 3.3 × 10 −4 .

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