Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21.

Sci Rep · 2018 · PMC5943590 · PMID 29743610

Europe PMC DOI

hedged sentences

0.0005

closest p · 0.0× alpha

0.0520

boldest claim

The sentences

nominally significantp < 5 × 10 −4actually significant

Genome-wide scan of nominally significant regions In a previous eight study meta-analysis, ~12,000 SNPs (INFO > 0.7, MAF > 0.01) were identified as having a nominally significant (p < 5 × 10 −4 ) association with all glioma, GBM, or non-GBM 4 .

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marginally significantp = 0.0520so close (0.05 < p ≤ 0.1)

In a case-only analysis a marginally significant difference was detected between males and females overall (p = 0.0520) and in GBM (p = 0.0428) (Supplemental Table 1 ).

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