Sequential drug treatment algorithm for agitation and aggression in Alzheimer's and mixed dementia.

J Psychopharmacol · 2018 · PMC5944080 · PMID 29338602

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difference was apparentno p-value reported

Memantine (NbN: glutamate receptor antagonist) This modulator of glutamatergic neurotransmission via N-methyl-D-aspartate receptor (NMDA) receptor antagonism has evidence from a meta-analysis of a positive effect in agitation and aggression ( Grossberg et al., 2009 ), but the observed difference was apparent only after six months of treatment.

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