Reduced penetrance of the PSEN1 H163Y autosomal dominant Alzheimer mutation: a 22-year follow-up study.

Authors of a recent meta-analysis of age of symptom onset in FAD families reported that ε4 allele carriers had earlier onset and ε2 carriers a later onset; however, these findings did not reach statistical significance or add to the explanation of the variance in age of symptom onset [ 9 ].

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