Structural and immunologic correlates of chemically stabilized HIV-1 envelope glycoproteins.

PLoS Pathog · 2018 · PMC5944921 · PMID 29746590

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showed a trendno p-value reported

By contrast, mice immunized with GLA-SOSIP trimer showed a trend towards more robust proliferation (~4-fold) and cytokine (~2-fold) responses to SOSIP than to GLA-SOSIP trimer re-stimulation, suggesting that cross-linked trimer may be less efficiently processed and/or presented in vitro to GLA-SOSIP trimer than to SOSIP trimer-primed memory T cells.

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