seasonal H1N1, H2N2, and H3N2) showed a trend toward loss of virulent PB1-F2 residues, IAV with zoonotic potential maintain a reservoir of virulent PB1-F2.
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Virulent PB1-F2 residues: effects on fitness of H1N1 influenza A virus in mice and changes during evolution of human influenza A viruses.
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