Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases.

Nat Commun · 2018 · PMC5951816 · PMID 29760442

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closest p · 1.0× alpha

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boldest claim

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nominally significantP < 0.05actually significant

In stage 2, we examined the 28 lead SNPs from stage 1 in the Asian-specific meta-analysis ( n = 8107) and found that 16, including the novel lead SNPs within or close to ADAMTS8 and DCN , were significant after Bonferroni correction ( P ≤ 1.79 × 10 −3 , 0.05/28), further three other SNPs including the two novel close to STAG1 and NDUFAF6 were nominally significant ( P < 0.05).

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