Utility of cell-free nucleic acid and circulating tumor cell analyses in prostate cancer.

Serial profiling in a proportion of patients also showed a trend for developing new mutations particularly in AR and BRCA. 47 Association of ctDNA and CTC profiling with response to therapy In a series of 65 patients with mCRPC initiated on enzalutamide, Wyatt et al . 48 collected serial cfDNA samples at baseline, 12 weeks, and end of treatment.

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