A review of soft-tissue sarcomas: translation of biological advances into treatment measures.

183 TWIST1 silencing in an in vivo xenograft model showed decreased metastatic burden, and regardless of metastasis status in patients, positive expression of TWIST1 showed a trend toward lower survival. 183 Another recent discovery was the oncogenic potential of KDM3A , a histone demethylase, in ES. 184 KDM3A silencing in vitro showed a 50% decrease in migration and invasion and a tenfold decrease in metastatic burden compared to controls (in mice). 184 MCAM , which is also involved in metastasis in other cancers, is a direct downstream target of KDM3A , and when silenced, recapitulated impaired proliferation and metastasis are observed with KDM3A silencing.

also in 53,322 other papers

70 , 71 Enrichment of both mutations was highly significant, and Behjati et al showed that 15 of 39 (38%) tumors had at least one driver mutation in signaling genes involved in angiogenesis. 70 , 71 More specifically, 10 of 39 (26%) samples had inactivating PTPRB mutations, whereas 3 of 34 (9%) samples likely had activating PLCG1 mutations. 70 PTPRB is a ty

also in 132,142 other papers