Mosquito saliva alone has profound effects on the human immune system.

PLoS Negl Trop Dis · 2018 · PMC5957326 · PMID 29771921

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a significant trendno p-value reported

When analyzing the serum cytokine response, we did observe a significant trend toward Th2 cytokine production at 7 days post-bite.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.