Epidermal glucocorticoid and mineralocorticoid receptors act cooperatively to regulate epidermal development and counteract skin inflammation.

There was an increased trend of S100a8 expression in DKO as compared to GR EKO or MR EKO although it did not reach statistical significance; however Mmp3 expression showed additive increases in DKO relative to single KOs (Fig. 2c ).

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