Compared to the WT cells, the OCT4A-KO cells exhibited higher sensitivity to both Cisplatin and Akti-1/2, although the difference of IC 50 values of Cisplatin between WT and 2-2 did not reach statistical significance (Fig. 6e ).
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Endogenous authentic OCT4A proteins directly regulate FOS/AP-1 transcription in somatic cancer cells.
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