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The COOH-terminal domain of huntingtin interacts with RhoGEF kalirin and modulates cell survival.

Sci Rep · 2018 · PMC5964228 · PMID 29789657

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However, the cytotoxicity of 100QHtt1-587 was only slightly greater but did not reach statistical significance relative to the cytotoxicity of 18QHtt1-587 (Fig. 5a ).

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