Although rIL-18/IL-4 treatment had a slight suppressive effect on the macroscopic arthritis score and incidence of arthritis in our previous research, it did not reach statistical significance [ 2 ].
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Suppression of Th1 and Th17 Responses and Induction of Treg Responses by IL-18-Expressing Plasmid Gene Combined with IL-4 on Collagen-Induced Arthritis.
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