The known unknown: the challenges of genetic variants of uncertain significance in clinical practice.

J Law Biosci · 2017 · PMC5965500 · PMID 29868193

Europe PMC DOI

hedged sentence

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closest p

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boldest claim

The sentences

quite significantno p-value reported

This question is less troublesome in the case of a downgraded VUS result, but the importance of an upgraded result making its way to a patient could be quite significant.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.