Loss of PUMA protects the ovarian reserve during DNA-damaging chemotherapy and preserves fertility.

2d, e ) showed a statistically significant decrease in the ovaries of WT mice treated with cisplatin, and a nonsignificant trend toward reduction in WT mice treated with cyclophosphamide (WT saline: 3.15 × 10 9 ± 0.42 × 10 9 μm 3 vs WT cisplatin: 1.54 × 10 9 ± 0.50 × 10 9 μm 3 , p < 0.05; vs WT cyclophosphamide 2.63 × 10 9 ± 0.25 × 10 9 μm 3 , p = 0.19).

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There was also a trend toward primary follicle depletion, although this did not reach statistical significance (Fig. 1c ).

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