Multiple common comorbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress, and myocardial stiffening.

LV end-systolic elastance also tended to be higher in these animals, although this failed to reach statistical significance ( Figure 6 I , P = 0.10), which correlated well with the maximal force development of single cardiomyocytes ( P = 0.006).

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