Protection Against Arthritis by the Parasitic Worm Product ES-62, and Its Drug-Like Small Molecule Analogues, Is Associated With Inhibition of Osteoclastogenesis.

Similarly, OPG mRNA levels were unchanged in PBS-treated animals compared to naïve animals, however, ES-62 treatment increased OPG mRNA in the BM of animals, although this did not reach statistical significance (Figure 2 G).

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