Diabetes Worsens Skeletal Muscle Mitochondrial Function, Oxidative Stress, and Apoptosis After Lower-Limb Ischemia-Reperfusion: Implication of the RISK and SAFE Pathways?

Front Physiol · 2018 · PMC5972292 · PMID 29872405

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highly significantno p-value reported

IR was followed by an increased cleaved caspase-3 expression in gastrocnemius, which was non-significant in non-diabetic animals and highly significant in diabetic rats.

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a strong trendno p-value reported

Taken together, the decreased levels of inactivated GSK-3β and the increased levels of cleaved caspase-3 in the diabetic animals after IR, denote a reduced protection against IRI and a strong trend for apoptosis (presumably through mPTP opening) and cell damage.

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