SHIP1 Deficiency in Inflammatory Bowel Disease Is Associated With Severe Crohn's Disease and Peripheral T Cell Reduction.

Overall, the presence of this fusion transcript represents a highly significant novel association with the SHIP1-deficient phenotype, with a conservatively estimated odds ratio (OR) of 153.0 (95% CI: 5.562–4209, P < 0.0001) compared to the healthy 13 controls, and an OR of 606.3 (95% CI: 22.76–16,150, P < 0.0001) compared to all available SHIP1-sufficient IBD and healthy control subjects ( n = 53).

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Although it did not reach statistical significance in the current cohort, more extensive analysis might also reveal an increase in IBD-associated neoplasia in SHIP1-deficient CD patients relative to other CD patients.

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