Does human endometrial LGR5 gene expression suggest the existence of another hormonally regulated epithelial stem cell niche?

Results Healthy human premenopausal endometrium demonstrated dynamic spatiotemporal regulation of LGR5 expression with high LGR5 expressing cells in the luminal and in the stratum basalis epithelium Full thickness whole endometrial tissue samples containing all endometrial layers and cell types from the oestrogen dominant, proliferative phase of the cycle showed a trend of higher LGR5 mRNA expression levels (as measured by qRT-PCR) compared with the samples from the progesterone dominant secretory phase of the menstrual cycle ( P = 0.5, Fig. 1 A).

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