Endothelial barrier protective properties of low molecular weight heparin: A novel potential tool in the prevention of cancer metastasis?

An additive effect was also observed following co‐incubation of endothelial cells with increasing concentrations of simvastatin in the presence of the 2.8 KDa LMWH fraction although the magnitude of barrier protective effect relative to simvastatin alone did not reach statistical significance (Figure 6 C). 4 DISCUSSION In the present study, we have demonstrated in vitro evidence to suggest that the exposure of endothelium to LMWH leads to enhanced endothelial barrier function.

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