Linking coupled motions and entropic effects to the catalytic activity of 2-deoxyribose-5-phosphate aldolase (DERA).

Interestingly, if one then extends this to placing all variants shown in Table 1 side by side, and ranking them according to their measured k cat / K M values, it can be seen that this loss of anti-correlated motions follows a clear trend across the mutants, with the variants with the lowest k cat / K M values ( i.e.

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