In vivo and in vitro studies of Cry5B and nicotinic acetylcholine receptor agonist anthelmintics reveal a powerful and unique combination therapy against intestinal nematode parasites.

PLoS Negl Trop Dis · 2018 · PMC5979042 · PMID 29775454

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0.2200

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showed a trendP = 0.22not close (p > 0.1)

Relative to water (placebo) control, 0.33 mg/kg pyrantel (labeled PYR in the figure) showed no significant impact on hookworm burdens (5% reduction, P = 0.87) whereas 1 mg/kg pyrantel showed a trend toward lower burdens that was not statistically significant (39% reduction, P = 0.22; Fig 5A ; S1 Table ).

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