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The JAK2 GGCC (46/1) Haplotype in Myeloproliferative Neoplasms: Causal or Random?

Int J Mol Sci · 2018 · PMC5979434 · PMID 29641446

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showed a trendno p-value reported
As regards the prognostic significance of the JAK2 haplotype GGCC_46/1 in AML cases, it was demonstrated that cases with a normal karyotype bearing the haplotype GGCC_46/1 showed a trend towards myelomonocytic proliferation and shorter disease-free survival and overall survival compared to GGCC_46/1 non carriers; on the other hand, the haplotype GGCC_46/1 had no impact on prognosis in the subgroup of AML with an abnormal karyotype [ 13 , 25 ].

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