PHLDA2 is a key oncogene-induced negative feedback inhibitor of EGFR/ErbB2 signaling via interference with AKT signaling.

Oncotarget · 2018 · PMC5982771 · PMID 29861842

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a strong trendno p-value reported

We also observed a significant correlation of PHLDA2 expression with histological subtype and a strong trend towards correlation of PHLDA2 expression with EGFR mutational status (Table 3 ).

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