Only IL-2 and IL-5 showed a trend towards higher expression in stimulated S1pr4 −/− although this was not statistically significant.
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S1P₄ Regulates Passive Systemic Anaphylaxis in Mice but Is Dispensable for Canonical IgE-Mediated Responses in Mast Cells.
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The sentences
These signals and their receptors may be significant factors in the susceptibility to, or severity of, anaphylaxis in allergic individuals [ 14 ].