We also quantified Arx expression in adult brain, and found a similar decrease at the mRNA level which however did not reach statistical significance (ratio Arx mRNA in Arx dup24/0 versus Arx wt/0 : 0.88 ± 0.15, n = 4, P = 0.47, unpaired t -test).
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A new mouse model of ARX dup24 recapitulates the patients' behavioral and fine motor alterations.
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0.4700
0.4700