Barely Significant
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Effects of varying doses of estrogen and caudal pressure on wheel running in orchidectomized male mice.

Physiol Rep · 2018 · PMC5987813 · PMID 29870160

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a clear trendno p-value reported
The urinary bladder content data are a secondary bioassay that demonstrates a clear trend illustrating increased levels of estrogens in the treatment animals do not result in changes to wheel running patterns.

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