Hematopoietic Stem Cells but Not Multipotent Progenitors Drive Erythropoiesis during Chronic Erythroid Stress in EPO Transgenic Mice.

Furthermore, we also examined MPPs in 4-week-old mice and found a clear trend toward lower numbers of Tg6 MPPs compared with WT littermates ( Figure S2 B).

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Interestingly, analysis of a set of 50 upregulated genes in MPPs (from 65 genes that were significantly changed and correlated with the CFUe down signature), showed a highly significant association with monocytes, while the majority of the downregulated genes correlated with B lymphocytes (Enrichr/Jensen TISSUES analysis; Figure 5 B) ( Kuleshov et al., 2016 , Lachmann et al., 2010 ).

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