Chronic social stress induces peripheral and central immune activation, blunted mesolimbic dopamine function, and reduced reward-directed behaviour in mice.

Neurobiol Stress · 2018 · PMC5991330 · PMID 29888303

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closest p · 1.6× alpha

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borderline non-significantp = 0.08so close (0.05 < p ≤ 0.1)

CSS mice had higher liver expression of Tdo1 (t (10) = 2.4, p < 0.04), Ido2 (t (10) = 2.6, p < 0.03), Tdo2 (t (10) = 2.6, p < 0.03), Kynu (t (10) = 2.3, p < 0.05) and 3-Haao (t (10) = 3.4, p < 0.007), and a borderline non-significant increase in Kmo (p = 0.08) ( Fig. 3 B).

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