Comparing smokers and non-smokers, the results showed a trend but reached no significance ( p = 0.077) for overall survival of patients (Fig. 4 ).
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Cancer stage and pack-years, but not p16 or HPV, are relevant for survival in hypopharyngeal and laryngeal squamous cell carcinomas.
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The sentences
In contrast, nicotine pack-years showed a highly significant correlation with survival in our patient collective.