Morphometric changes over the whole brain in caffeine-containing combination-analgesic-overuse headache.

Mol Pain · 2018 · PMC5992799 · PMID 29877133

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did not reach statistical significanceno p-value reported

The volume-gain regions tended to decrease and volume-loss region tended to increase but did not reach statistical significance in patients with psychological comorbidities and of higher headache frequency compared to those with no definite psychological comorbidities and of lower headache frequency.

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