Estrogen-Related Receptors Mediate the Adaptive Response of Brown Adipose Tissue to Adrenergic Stimulation.

The two nuclear transcriptional co-regulators that drive mitochondrial biogenesis and Ucp1 expression in BAT, Ppargc1a and Ppargc1b ( Puigserver et al., 1998 , Uldry et al., 2006 ), were moderately up- and down-regulated, respectively, at the mRNA level ( Figure 2 L); assessment of their protein expression showed a trend for both co-regulators to be at higher levels in ERRαγ Ad−/− than WT BAT ( Figure S2 D).

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