Brain Cell Type Specific Gene Expression and Co-expression Network Architectures.

For example, when considering the 100 top genes most enriched in a cell type, there was a highly significant enrichment in astrocytes (Fold Enrichment (FE) = 1.4e8, p = 4.2e-103), endothelial cells (FE = 1.2e8, p = 2.8e-86), microglia (FE = 1.2e8, p = 2e-86), neurons (FE = 4.2e7, p = 3.7e-30), and oligodendrocytes (FE = 2e8, p = 6.4e-163) across the five data sets.

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However, we still identified nominally significant rank correlations between estimated relative astrocyte proportions and IHC quantifications for GFAP in the parietal cortex (ρ = 0.27, p = 0.01) as well as estimated relative microglia proportions and IHC quantifications for IBA1 in the hippocampus (ρ = 0.38, p = 0.0003).

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