While the lowest doses of W146 (0.0025–0.05 ug/ml) produced a variable increase in heart rate that did not reach statistical significance, the two higher doses of 0.5 or 1 ug/ml consistently restored the heart rate of Tbx5 morphants to statistically normal levels (Figure 6G ).
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Post-transcriptional Modulation of Sphingosine-1-Phosphate Receptor 1 by miR-19a Affects Cardiovascular Development in Zebrafish.
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