Hedgehog signalling in the tumourigenesis and metastasis of osteosarcoma, and its potential value in the clinical therapy of osteosarcoma.

Cell Death Dis · 2018 · PMC5999604 · PMID 29899399

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showed a trendno p-value reported

In an animal model of pulmonary metastasis, the cyclopamine group showed a trend of ~20% inhibition of the metastasis, suggesting that cyclopamine has obvious inhibitory effects on pulmonary osteosarcoma metastasis in vivo; however, marked side effects, mainly skin ulcerations, are caused by cyclopamine/ethanol/triolein administration 101 .

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