Short-term Low-Dose mTORC1 Inhibition in Aged Rats Counter-Regulates Age-Related Gene Changes and Blocks Age-Related Kidney Pathology.

Gene pathways up-regulated by age in all three tissues were complement genes, apoptosis and interferon gamma response pathway genes, albeit this upregulation was highly significant (hypergeometric test, p < 10 −12 – 10 −20 ) in the old kidney and less significant in the old liver and skeletal muscle ( Figure 2 ).

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It should be noted that there are trends towards counter-regulation of age-perturbed gene pathways by RAD001 in skeletal muscle and liver, but these did not reach statistical significance once the data were corrected for FDR (false-discovery rate).

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