miR-146a suppresses 5-lipoxygenase activating protein (FLAP) expression and Leukotriene B4 production in lung cancer cells.

However, there was a highly significant correlation between high FLAP expression and lower overall probability of survival in the 720 patients with lung adenocarcinoma ( P = 3.1 × 10 -7 , HR = 1.86) (Figure 1C ).

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Analysis of data from 1,926 NSCLC patients showed a trend of high FLAP expression correlating with a lower overall probability of survival, but this was not statistically significant ( P = 0.15, HR = 1.1) (Figure 1A ). 1,244 of these patients had an NSCLC subtype associated with their data.

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