The model‐based simulations showed a clear trend toward higher P unfavorable under previous thrice‐weekly dosing compared to new once‐daily dosing RNTCP recommendations. 7 , 9 The new RNTCP guidelines, similar to guidelines in other settings, still assumes similar mg/kg dose levels across weight bands, disregarding maturation processes occurring throughout childhood. 32 Thus, under previous and new RNTCP dosing recommendations, P unfavorable was at the highest in the first (previous: 6–10 kg and new: 4–7 kg) weight band due to a low RIF exposure when compared to the older children.
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Suboptimal Antituberculosis Drug Concentrations and Outcomes in Small and HIV-Coinfected Children in India: Recommendations for Dose Modifications.
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