Barely Significant
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Heroin Abuse Results in Shifted RNA Expression to Neurodegenerative Diseases and Attenuation of TNFα Signaling Pathway.

Sci Rep · 2018 · PMC6006288 · PMID 29915338

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quite significantno p-value reported
It is apparent that the global public health impact of this drug is quite significant.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.