The Cefazolin Inoculum Effect Is Associated With Increased Mortality in Methicillin-Susceptible <i>Staphylococcus aureus</i> Bacteremia.

In this study, 57.5% of isolates were positive for the CzIE (defined by the authors of the study as a 4-fold or greater increase in cefazolin MIC at high inoculum), and although there was a trend toward increased treatment failures in CzIE-positive isolates (48% vs 25%), this did not reach statistical significance [ 27 ].

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