Advances in the discovery of cathepsin K inhibitors on bone resorption.

With biochemical potency on the rat protein and reasonable PK following 50 mg/kg oral dosing ( C max = 9.2 μg/mL; AUC =103.9 μgh/mL), 50 showed a trend toward increased BMD in OVX rat femur following b.i.d. dosing for 42 days 14 .

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