COX-2-derived PGE<sub>2</sub> triggers hyperplastic renin expression and hyperreninemia in aldosterone synthase-deficient mice.

Pflugers Arch · 2018 · PMC6013527 · PMID 29455241

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did not reach statistical significanceno p-value reported

The deletion of the EP4 receptor specifically in renin-expressing cells after doxycycline-dependent induction (AS −/− /mRen-rtTAm2/LC1 Cre/EP4 fl/fl ) led to a moderate decrease in renin mRNA by around 25% whereas the decline in plasma renin concentrations did not reach statistical significance (Fig. 6 ).

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