Cadmium-Associated Differential Methylation throughout the Placental Genome: Epigenome-Wide Association Study of Two U.S. Birth Cohorts.

In our meta-analysis, one of the top six loci from that study, cg04528060 on chromosome 4 within the ADP-ribosylation factor-like 9 ( ARL9 ) gene, demonstrated a nominally significant association with Cd ( β 1 = − 0.49 , p -value = 0.014 ), with the same direction of effect.

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Additionally, the coefficients for cg15345741 and cg16768966 retained highly significant p -values ( < 1 × 10 − 5 ) after PCT adjustment.

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