Regulation of somatostatin receptor 2 in the context of antidepressant treatment response in chronic mild stress in rat.

The lack of a significant interaction between the stress and IMI treatment was observed in the anterodorsal part of the medial amygdaloid nucleus (MeAD) [interaction, F (2, 36) = 1.40; ns], while the treatment factor was highly significant [treatment factor, F (1, 36) = 24.20; p < 0.0001] and the impact of stress was also statistically significant [stress factor, F (2, 36) = 3.75; p < 0.05].

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In the present study, using [ 3 H]Domperidone, we observed an increase in D 2 R binding upon chronic IMI treatment but this effect did not reach statistical significance.

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