Expanding the Potential Therapeutic Options for Remote Ischemic Preconditioning: Use in Multiple Sclerosis.

In an early study, investigators randomized 443 patients with acute ischemic stroke to receive pre-hospital ReIP or sham procedure before thrombolysis, and results showed a trend toward less tissue infarction although overall clinical and imaging endpoints were negative ( 13 ).

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In a recent, but smaller trial, involving 26 patients with acute ischemic stroke, ReIP showed a favorable trend toward improving clinical outcomes at 3 months as well as an increase in the circulating levels of a putative biomarker, heat shock protein-27 ( 14 ).

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