Double staining of blood vessels (CD31) and proliferative cells (Ki67) revealed a lower median count of proliferative tumor endothelial cells (24 [19 31.5] versus 45 [22.5 49], Figure 4C–4F ), though it did not reach statistical significance (Mann-Whitney U test: p = 0.175).
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Targeting the extradomain A of fibronectin allows identification of vascular resistance to antiangiogenic therapy in experimental glioma.
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